A 57-year-old man from Hastings was hospitalized after his motorcycle collided with a car on Highway 61 around 10:00 Saturday night.
The State Patrol says Robert John Voelker was southbound on his Harley when it struck a car that was northbound and turning onto Highway 55.
Voelker was taken to Regions Hospital in St. Paul. His injuries are considered life threatening.
The car driver was 34-year-old Brian Taylor Hopkins of Mankato and his passenger was 34-year-old April Marie Hopkins of Mankato. Neither was injured.
Saturday was the annual Fall Flood Run, with as many as 30,000 motorcyclists traveling between the Twin Cities and Winona. So far this season, 45 motorcyclists have died on Minnesota roads.